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Original Article
Incidence and Perinatal Risk Factors of Respiratory Distress Syndrome of Newborn
Yun Sil Chang, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(8):1065-1077.   Published online August 15, 1994
Over a continuous 4-year period, from January 1989 till December 1992, 7,100 infants were born in Department of Obstetrics and admitted to Nursery or Neonatal Intensive Care Unit of Department of Pediatrics of Seoul National University Children's Hospital. Among them, 126 cases were diagnosed as respiratory distress syndrome (RDS) of newborn. The total incidence of RDS among all the newborns(inborn)was 1.77%....
A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro
Seong Yong Jung, Thi Hyung Park, Chong Woo Bae, Chang Il Ahn
Clin Exp Pediatr. 1994;37(8):1048-1054.   Published online August 15, 1994
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent...
Diagnostic value and Relationship of the between Stable Microbubble rating Test and Shake Test for the Prediction of Neonatal Respiratory distress Syndrome
Seong Jin Ha, Dong Kyun Ryu, Oh Kyung Lee, Wan Seob Kim
Clin Exp Pediatr. 1994;37(5):620-627.   Published online May 15, 1994
Respiratory distress syndrome (RDS) in the newborn infants remains a major cause of mortality and morbidity in the newborn period despite much improvements in neonatal intensive care and artificial ventilatory techniques. Gastric fluid was obtained from 151 patients within 6 hours after delivery. The sensitivity, specificity, and predictive value of the simple shake test (133 cases) and stable microbubble rating...
Improvement of Thoracic Pressure-Volume, Complincace and Histological Characteristics in Premature Newborn Rabbit after Treatment of Bovine Purified Natural Surfactant-Phospholipid
Chong-Woo Bae, Chang Il Ahn, Haruo Maeta, Tetsuro Fujiwara
Clin Exp Pediatr. 1994;37(2):157-166.   Published online February 15, 1994
We had previously reported the purification of bovine lung natural surfactant-phospholoipd (PNS-L) and the assessment of it's surface physical properties in vitro. To observe the clinical effectiveness of PNS-L in vivo, the degree of improvement of thoracic pressure-volume, compliance and histological changes following PNS-L instillation in premature rabbits with respiratory distress syndrome (RDS) were investigated. Rabbits, delivered prematurely by cesarean section...
The Relationship between Spontaneous Diuresis and Changes of Pulmonary Function in Infants with Respiratory Distress Syndrome
Byeong Hyun Kim, Jae Kag Choi, Yeon Kyun Oh, Kwang Soo Oh, Hyang Suk Yoon, Chong Cuk Kim
Clin Exp Pediatr. 1993;36(8):1094-1100.   Published online August 15, 1993
To evaluate the relationship between spontaneous diuresis and improvement of pulmonary function in respiratory distress syndrome, 15 premature neonates requiring mechanical ventilation for RDS, who admitted in NICU of Wonkwang University Hospital from January 1990 to June 1992, were studied. The results were as follows(results are mean¡¾SEM) 1) Mean birth weight of study infants was 1.82¡¾0.08Kg, and mean gestational age was 32.80¡¾0.54...
Comparison and diagnostic Accuracy of Stable Microbubble Rating Test and Shake Test for the Early Detection of Respiratory Distress Syndrome
Hyeon Gon Kim, Sang Hyun Byun, Young Hun Chung
Clin Exp Pediatr. 1993;36(7):913-918.   Published online July 15, 1993
Respiratory distress syndrome of preterm infants remains a significant cause of morbidity and mortality. Early, just after birth, prediction and recognition of RDS is so important. The precision and reliability of the stable microbuble test (SMR) and shake test as a predictor of respiratory distress syndrome were studied. A 11-=neonate who was born at Chungnam National University Hospital between November 1991...
Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome: A Collective Evaluation of Trials from 16 Hospitals
CW Bae, YD Kwon, SJ Ko, KS Kim, HM Kim, WS Park, SH Byun, CS Son, HS Ahn, SG Lee, YP Chang, YJ Chung, KS Cho, KH Cho, KC Choeh, MJ Chey, JH Choi, JK Yoon, CI Ahn, S Chida, T Fujiwara
Clin Exp Pediatr. 1993;36(2):244-265.   Published online February 15, 1993
Surfactant replacement therapy in neonates with respiratory distress syndrome (RDS) has been introduced in our country since May 1990. The purpose of this study was to assess the effect and short-term outcome of surfactant replacement for neonatal RDS using collective data of uncontrolled trials from different hospitals in Korea. For the period May 1990 to Dec. 1991, a total of 68...
Diagnostic Accuracy of Stable Microbubble Rating Test for the Early Detection of Neonatal Respiratory Distress Syndrome
Jung-Sam Jun, Chy-Hyung Park, Jong-Woo Bae, Chang-Il Ahn
Clin Exp Pediatr. 1992;35(10):1361-1368.   Published online October 15, 1992
Respiratory distress syndrome(RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventiratory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested on RDS infants by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement...
Case Report
2 Cases with Adult Respiratory Distress Syndrome in Infant and Young Child
Hye Jung Joo, Im Jae Park, Joon Soo Lee, Soo Young Lee, Byeung Ju Jeoung, Kyu Earn Kim, Ki Young Lee, Hyunee Yim, Soon Won Hong, Woo Hee Jung
Clin Exp Pediatr. 1992;35(8):1118-1126.   Published online August 15, 1992
Adult respiratory distress syndrome has been described as a clinical syndrome of respiratory distress and need for mechanical ventilation with positive end-expiratory pressure, diffuse pulmonary infiltration on thoracic roentgenogram, impaired pulmonary compliance, decreased lung volumes and capacities, increased alveoloarterial oxygen gradient and hyaline membrane formation. It is the clinical manifestation of injury to the terminal alveolocapillary unit as a result...
Adult Respiratory Distress Syndrome in Infancy
Hoo Jae Hann, Young Mi Hong, Seung Joo Lee
Clin Exp Pediatr. 1992;35(2):245-251.   Published online February 15, 1992
Adult Respiratory distress Syndrome (ARDS) is a clinical entity characterized by respiratory distress and diffuse pulmonary infiltrates due to increased permeability after various kinds of insult to alveolar-capillary membrane. We experienced a case of ARDS in a 3-1/2 month old girl after Pseudomonas pneumonia, cardiac arrest and generalized convulsion. This is the report on her clincal and autopsy findings with brief review...
Original Article
Surfactant replacement therapy in neonatal respiratory distress syndrome.
Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1211-1222.   Published online September 30, 1991
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS...
A clinical study on the idiopathic respiratory distress syndrome of the newborn: comparison of radiographic and clinical findings.
Byoung Yul Lim, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn, Sun Wha Lee
Clin Exp Pediatr. 1991;34(1):16-23.   Published online January 31, 1991
Idiopathic respiratory distress syndrome (IRDS) of the newborn remains an important and signifi- cant cause of morbidity and mortality despite of improvement in neonatal care. The clinical and radiologic features observed are the results of surfactant deficiency combined with a highly compliant chest wall. We have been applied the clinical and radiologic features in the diagnosis of IRDS. In 1974, Bomsel et al reported the...
Thyroid function Study in Respiratory distress Syndrome.
Sung Soo Kong, Mi Young Chung, Dong Hyunk Kum
Clin Exp Pediatr. 1990;33(10):1394-1398.   Published online October 31, 1990
It has been known that intrauterine thyroid hormone deficiency may be one of the factors predis- posing to RDS in premature infants. L-thyroxine has been shown to increase the production opf lung surfactant, widely accepted as deficient in RDS infants, as association between lung immaturity and fetal thyroid function is postulated. The authors investigated thyroid hormone concentration at birth and 5, 15 days of...
Cord Blood Insulin Concentration in Premature Neonates with Respiratory Distress Syndrome.
Soo Jung Keum, Rak Won Choi, Mi Youn Chung, Dong Hyuck Kum
Clin Exp Pediatr. 1989;32(10):1402-1407.   Published online October 31, 1989
Insulin seems to exert an inhibitory effect on lung maturation. The incidence of respiratory distress syndrome in neonates of diabetic mothers is significantly greater than that observed in age-and weight-matched controls. Thus hyperinsulinemia may be an important factor in the developemnt of RDS. We investigated the relationship between cord blood insulin concentration and subsequent develop- ment of RDS in 32 premature neonates born at Koryo...
Clinical Application of Shake test od Gastric Aspiretes for the Prediction od Respiratory Distress Syndrome in the Newborn infants.
In Sang Jeon, Hann Tchah, Myoung Jae Choi, Beyng Il Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1989;32(3):349-358.   Published online March 31, 1989
To study the predictive value of gastric aspirates shake test on respiratory distress syndrome (RDS) in the newborn infants, we carried out the shake test on gastric aspirates of all newborn who admitted to NICU of Seoul National University Hospital from July 1986 to December 1987. We successfully carried out gastric aspirates shake test on 96 newborn infants and analyzed the relation between gastric...
Risk Factors for Retinopathy of Prematurity (Retrolental Fibroplasia)
Beyong Il Kim, Jung Hwan Choi, Chong Ku Yun, Jae Heung Lee, Son Moon Shin
Clin Exp Pediatr. 1987;30(10):1092-1099.   Published online October 31, 1987
We studied 51 premature babies who were admitted to the N.I.C.U. of S.N.U.H., managed with oxygen with or without artificial ventilation due to respiratory distress, and examined by indirect ophthalmoscopy between April 1, 1982 and March 31, 1986. The results were as follows; 1. Among 51 premature babies, retinopathy of prematurity developed in 12 cases (24%). 2. The high distribution of retinopathy of prematurity was observed in...
Respiratory Distress Syndrome of the New born Infants and Complications of Pregnancy.
Yoon Joo Choi, Eun Ai Lee, Seung Joo Lee, Keun Lee
Clin Exp Pediatr. 1983;26(2):118-123.   Published online February 28, 1983
A group of 514 newborn infants with gestational ages between 28 weeks and 36 weeks were studied for the influence of pronolonged rupture of amniotic membranes and maternal hype- rtension. during pregnancy on. the incidence of Idiopathic Respiratory Distress Syndrome (IRDS). The incidence of IRDS in. complicated pregnancy is that significantly lower than in the control groups. (8.9% vs 18.8%, p<0.05) The occurence of...
Case Report
A case of Pierre-Robin Syndrome.
Soon Ja Han, yeongok bang, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1982;25(4):419-422.   Published online April 30, 1982
Micrognathia, cleft palate and glossoptosis, a combination of anomalies known as Pierre Robin syndrome, causes severe respiratory and alimentary difficulties in affected infants. With appropriate care and treatment, mental development can be made normal. But about 10~25% of children become retarded. We have experienced above case in a female infant, aged 6 months. She was acmitted on account of respiratory...
Original Article
Form Stability Test on Gastric Aspirate and Respiratory Distress Syndrome in Newborn Baby.
Byung Do Nam
Clin Exp Pediatr. 1981;24(5):437-444.   Published online May 15, 1981
Form stability test on gastric aspirate was performed on 102 cases of newborn within 30 minutes afterbirth, who were admitted to Special Care Unit of St. Benedict Hospital from Sep. 1977 to Aug. 1979, and following results were obtained. 1) There was no differnce between amniotic fluid and gastric aspirate in control group. 2) In all newborn infants with positive...
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